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People with high neuroticism indexes are at risk for the development and onset of common mental disorders, Galen of Pergamom popularized the idea that mixes of four bodily fluids or humours resulted in four personality types or temperaments.

Various personality tests produce numerical scores, and these scores are mapped onto the concept of "neuroticism" in various ways, which has created some confusion in the scientific literature, especially with regard to sub-traits or "facets".

Individuals who score low in neuroticism tend to be more emotionally stable and less reactive to stress.

Neuroticism has been found to be positively correlated with the BIS scale, and negatively correlated with the BAS scale.

Questions used in many neuroticism scales overlap with instruments used to assess mental disorders like anxiety disorders (especially social anxiety disorder) and mood disorders (especially major depressive disorder), which can sometimes confound efforts to interpret N scores, and makes it difficult to determine whether each of neuroticism and the overlapping mental disorders might cause the other, or if both might stem from other cause. It found that high neuroticism is predictive for the development of anxiety disorders, major depressive disorder, psychosis, and schizophrenia, and is predictive but less so for substance abuse and non-specific mental distress.

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Neuroticism has also been found to be associated with death.

In 2007, Mroczek & Spiro found that among older men, upward trends in neuroticism over life as well as increased neuroticism overall both contributed to higher mortality rates.

They tend to be calm, even-tempered, and less likely to feel tense or rattled.

Although they are low in negative emotion, they are not necessarily high on positive emotion.

A 2004 meta-analysis attempted to analyze personality disorders in light of the five-factor personality theory and failed to find meaningful discriminations; it did find that elevated neuroticism is correlated with many personality disorders.