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Reconsolidating

In recent decades, advancements in cellular preparations, molecular biology, and neurogenetics have revolutionized the study of consolidation.

However, lithium chloride is not an amnestic – it doesn’t block protein synthesis. The implication of the lithium experiment is that According to the consolidation/reconsolidation hypothesis, recently acquired or reactivated memories are transformed progressively from an initially labile state into a stable form, through a protein-dependent process.

Preventing these processes should result in an irreversible impairment.

and occurs within the first few hours after learning, and systems consolidation, where hippocampus-dependent memories become independent of the hippocampus over a period of weeks to years.

Recently, a third process has become the focus of research, reconsolidation, in which previously-consolidated memories can be made labile again through reactivation of the memory trace.

The ‘reconsolidation’ hypothesis holds that when a memory is recalled, its molecular trace in the brain becomes plastic.

On this view, a reactivated memory has to be ‘saved’ or consolidated all over again in order for it to be stored.

The two proposed the perseveration-consolidation hypothesis after they found that new information learned could disrupt information previously learnt if not enough time had passed to allow the old information to be consolidated.

Systematic studies of anterograde amnesia started to emerge in the 1960s and 1970s.

Gisquet-Verrier P, Lynch JF 3rd, Cutolo P, Toledano D, Ulmen A, Jasnow AM, & Riccio DC (2015).

Integration of New Information with Active Memory Accounts for Retrograde Amnesia: A Challenge to the Consolidation/Reconsolidation Hypothesis?

Molaison also showed signs of retrograde amnesia spanning a period of about 3 years prior to the surgery suggesting that recently acquired memories of as long as a couple years could remain in the MTL prior to consolidation into other brain areas.